Original Mildronate from Grindex (Latvia)

500mg of Meldonium dihydricum x 60 hard capsules

Price: 35,00 €

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Mildronate® (aka Mildronats, Meldonium, Mildronat) is a nootropic, vasodilator and CNS stimulant that can unlock your intellectual and physical potential. Mildronate is a structural analogue of gamma-butyrobetaine, a substance contained in every cell of the human body. Mildronate restores the balance between oxygen supply and demand in cells, and removes toxic metabolic products accumulated in cells protecting them from damage. It also possesses an invigorating stimulant effect. Oxygen delivery and utilization by both muscle & brain cells is enhanced. Mildronate is one of Latvia's most exported products. Benefits:

  • Improves Mental Processes (Memory, Learning, Focus, Concentration, Processing of Information);

  • Reduces Fatigue, Increases Energy Levels, Motivation & Alertness;

  • Improves Athletic Training & Competitive Performance;

  • Excellent for Athletes to Improve Stamina;

  • Improves Microcirculation & Oxygen Delivery;

  • Protects Cells from Intoxication.

Meldonium is the leading agent of the cardiovascular group, antiischemic agent of a metabolic action. Acts as antiischemic cell protector in patients with angina pectoris, chronic heart failure, brain circulation disorders. Improves physical capacity and mental function in the case of ischemia and in healthy people. Due to its unique mechanism of action Meldonium, depending on the prescribed dose, is widely used for the treatment of different heart and vascular diseases, as well as for the improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period.

Suggested Use:

  • As a general nootropic take one 500mg capsule each morning. May increase to one 500 mg capsule twice daily if desired and well tolerated.

  • For improved athletic performance take 1 to 2 - 500mg capsule twice daily.

  • Do not take within 8 hours of planned bedtime.

  • Maximum daily dose is 2000mg (4 tablets).

What is meldonium and why did Maria Sharapova take it?

Meldonium is also known as mildronate, it increases exercise capacity in athletes and the Olympic figure skating champion Ekaterina Bobrova admitted to testing positive to the drug on Monday (07/03/16).

Tennis star Maria Sharapova revealed on Monday (07/03) that she had failed a drugs test at this year’s Australian Open and immediately brought meldonium to the world’s attention. Nike and Tag Heuer cut ties with Maria Sharapova. Meldonium is also known as mildronate, the name by which Sharapova knew the drug, having taken it since 2006. But what do we know about the substance, why was the Russian taking it and why was it banned only this year?

• Meldonium is used to treat ischemia: a lack of blood flow to parts of the body, particularly in cases of angina or heart failure.
• It is manufactured in Latvia and only distributed in Baltic countries and Russia. It is not approved by the Food and Drug Administration for use in the United States and is not authorised in the rest of Europe.
• It increases blood flow, which improves exercise capacity in athletes.
• WADA found “evidence of its use by athletes with the intention of enhancing performance” by virtue of carrying more oxygen to muscle tissue.
• The decision to add meldonium to the banned list was approved on 16 September 2015, and it came into effect on 1 January 2016. WADA had spent the previous year monitoring the drug before adding it to the banned list.
• The drug was name-checked in the latest investigative documentary on Russian doping reforms by the German Hajo Seppelt on Sunday. The documentary referred to a 2015 study in which 17% of Russian athletes (724 of 4,316) tested were found to have meldonium in their system. A global study found 2.2% of athletes had it in their system.
• L’Equipe reported that the scientific advisor to the French Agency Against Doping (AFLD), Professor Xavier Bigard, said in interviews with athletes at last year’s European Games in Baku that a wide proportion of athletes admitted taking meldonium.
• It is classed as an S4 substance under the WADA code, which addresses hormone and metabolic modulators.
• The standard ban under the World Anti-Doping Code is four years.
• A memo was sent out to athletes by Russia’s anti-doping agency last September informing them of the decision to ban its use.
• Sharapova says she has been taking the drug for 10 years after she was regularly falling ill. She had a magnesium deficiency and family history of diabetes.
• Several athletes have been suspended since the turn of 2016 after testing positive for the dug. Abebe Aregawi, the 2013 women’s 1,500m world champion, has been provisionally suspended after meldonium was found in a sample she provided. Endeshaw Negesse, the 2015 Tokyo marathon champion, was also banned after reportedly testing positive for the same substance. Others include: Eduard Vorganov, a Russian cyclist, Ekaterina Bobrova, a Russian ice dancer, Russian speed skaters Pavel Kulizhnikov, Semion Elistratov and Ekaterina Konstantinova, swimmer Yulia Efimova, boxer Alexander Povetkin, volleyball player Alexander Markin, rugby players Aleksej and Alena Mihaltsova, biathletes Eduard Latypov, Olga Abramova and Artem Tyschcenko.

The Latvian company Grindeks, which manufactures meldonium, told the Associated Press that four to six weeks is a common course. “Depending on the patient’s health condition, treatment course of meldonium preparations may vary from four to six weeks. Treatment courses can be repeated twice or thrice a year,” the company said in an emailed statement.

“Only physicians can follow and evaluate patient’s health condition and state whether the patient should use meldonium for a longer period of time.” While Grindex has previously stated that the drug can provide an “improvement of work capacity of healthy people at physical and mental overloads and during rehabilitation period,” the company said that it believes the substance would not enhance athletes’ performance in competition and might even do the opposite.

“It would be reasonable to recommend them to use meldonium as a cell protector to avoid heart failure or muscle damage in case of unwanted overload,” the company said. Grindeks said that, in sports activity, the drug slows down how the body breaks down fatty acids to produce energy.

Grindex did not comment when asked whether someone with the symptoms Sharapova described would be a suitable patient for meldonium. The company said it was designed for patients with chronic heart and circulation conditions, those recovering from illness or injury and people suffering with “reduced working capacity, physical and psycho-emotional overload”.

The AP was able to buy vials and tablets of meldonium over the counter in Moscow on Tuesday. Accompanying documentation stated that side-effects could include blood pressure changes, irregular heartbeat and skin conditions.

A German anti-doping expert Mario Thevis, who helped to develop the test for meldonium, said that testing was reliable despite the drug’s recent addition to the WADA banned list.

“As a scientist, you can never say 100%, but the substance is non-natural, which means that it can be readily differentiated [from naturally occurring substances],” said Thevis, a professor at the anti-doping laboratory in Cologne. “It can be tested as reliably as any other doping agent.”

He added: “There is a potential of the substance to enhance performance and it has been described as a means to facilitate recovery and to enhance physical as well as mental workload capabilities.”

Thevis said the drug appeared most prevalent in Eastern European countries. “The fact that the substance is available as a prescription drug as well as over the counter in certain formulations, and it is only approved, such a substance, in Eastern European, Baltic countries, the probability is that the athlete who is originating from that region has more contact to that sort of substance. It’s a logical consequence,” he said.

Russia’s sports minister, Vitaly Mutko, said he expected more Russian athletes to test positive for meldonium. “It’s clear that more upheaval related to this substance awaits us,” he told the Tass agency. “People who do this knew all the responsibility.”

Although meldonium was banned in January, the decision to ban it had been announced by WADA and sports organisations as early as September 2015. Sharapova said she received an email with information on the changes in December but did not read it at the time.


Commentary of the inventor of Mildronate, Ivars Kalvins:

I’m indignant that sportsmen are being repressed and that mildronate is induced in this list of banned drugs, that sportsmen are prohibited to use. In reality it was their only help in situations when they train with the maximum load and any moment can come with an acute lack of oxygen in the heart that usually ends with microstroke, big stroke or death. If this [drug] is banned then we will quite often see instances of deaths on field of highly trained sportsmen or men in their prime years, ” says Ivars Kalvins.

They look at the name, see that this drug is found in the blood of many sportsmen and rejoice that it obviously need to be banned. That is it! This has got no substantiation, because there haven’t been made any researches that would prove that, for instance, such sportsmen who have received Mildronate injections before start  could suddenly run faster. There is none.

Kalvins points out that Mildronate has never been doping substance: „It has been used by patients and healthy persons, by athletes and non-athletes for 32 years, but suddenly turns out it’s doping.

Mildronate restores the level of natural substances in organism and for the moment these substances aren’t there, the protection that Mildronate offers helps the human to overcome the lack of oxygen.

"That is why it is meant both for heart patients, who have damaged artery and for sportsmen, when he has violated the maximum permissible load and blood no longer provides oxygen in the same amount, which makes the heart muscle to start dying. There is no discussion about him running slower or faster. With such a ban, human rights are violated and for sportsman, they are the same as for everyone else. He also wants to live.says Kalvins.



Original Mildronate from Grindex (Latvia)

500mg of Meldonium dihydricum x 60 hard capsules

Buy Online Price: 35,00 €

Standard international postage from Europe (4 to 15 working days)


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